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A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

based on consistent formation of -helical structure in initial rounds of structure calculations in which no hydrogen bond restraints were defined), inter-molecular PRE restraints (4 non-interacting copies of the spin label to account for different spin label orientations), inter- and intra-molecular NOE restraints, and ambiguous distance restraints for residues showing CSPs upon binding

Side effects are generally minimal

But theres a link between oxidative stress and balding as well

The clinical significance of metformin-induced vitamin B12 deficiency ranges from milder manifestations, such as fatigue and paraesthesia, to severe features like pancytopenia and degeneration of the spinal cord