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These results confirm that proline at position 3 (P3) is a critical residue for BPC157-mediated endothelial cell proliferation

10.1053/j.gastro.2019.10.035

Redox Biol 28:101343 Warren RB, Mrowietz U, von Kiedrowski R, Niesmann J, Wilsmann-Theis D, Ghoreschi K, Zschocke I, Falk TM, Bldorn-Schlicht N, Reich K (2017) An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

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This is attributed to distribution of the administered drug between the central compartment and tissue (peripheral compartment)