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These patients often require B12 injections to maintain adequate levels regardless of dietary intake
The GPXs mediate the same reaction as catalase, namely, the recycling of hydrogen peroxide into water
Thus, absence of GPx1 in knockout mice was found to augment neuronal damage in the middle cerebral artery occlusion ischemia-reperfusion (MCAO) model of stroke, with increased infarct volume and increased apoptosis in brains of GPx1 / mice compared with wildtype mice [106]
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In MASLD, elevated CCL2 levels exacerbate liver inflammation by enhancing monocyte and macrophage infiltration [196]
