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Curcumin-loaded PLGA nanoparticles exhibited excellent biocompatibility, neuroprotective effects, and improved learning and memory ability in APP/PS1 mice (Zeng et al., 2023)

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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability

10.1371/journal.pone.0074860 PLoS One Summary Keywords ubiquitination, deubiquitination, transcriptional regulation, molecular clock, protein homeostasis Citation Costanzo KM, Prifti MV, Todi SV and Mohan RD (2025) The ubiquitin-proteasome system in circadian regulation

So no alcohol the day or injection and drink lots of water