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Science 1997;275(5296):67-70
A clinical research study showed that erbB2 -overexpressing breast tumor demonstrates reduced sensitivity to methotrexate, cyclophosphamide, and CMF (combination cyclophosphamide, methotrexate, and 5-FU) (149)
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Small tweaks to technique changing the site, spacing injections differently, or modest shifts in needle angle can reduce repeated soreness
