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Additionally, mitochondrial stress may disrupt Ca + homeostasis, activate the mitochondrial permeability transition pore (mPTP), and facilitates the efflux of mitochondrial matrix Ca + , leading to mitochondrial swelling, outer membrane rupture, and subsequent dysfunction (6062)

doi: 10.1002/jca.2920100308 48 GuglielmiCArceseWDazziFBrandRBunjesDVerdonckLFet al

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Furthermore, it is apparent that researchers have focused on only a few antioxidants (i.e., vitamin E, selenium, etc.)