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J Clin Psychopharmacol 2012;32:797-803

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The novel mechanism by which 4-HNE inhibits NLRP3 is through its ability to directly bind to the critical domains of NLRP3, disrupting its interaction with the adapter protein NEK7, a key step in inflammasome activation, thereby preventing caspase-1 activation

Nine genes assigned to the oxidative phosphorylation pathway had reduced transcript levels including qoxA (-2.0), ndh2 ( 1.7), and atpACDEFGH ( 2.6 to 3.3)

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