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[Para 21 0] Recently, the symptom complex had expanded to include loose stools that had been present for one month

RO(N)S are an integral part of normal cell signaling, responsible for reversible redox-based (oxidation/reduction) post-translational modifications (redox PTMs) of reactive and redox-sensitive sulfur-containing amino acid residues of cell signaling pathway components in a highly selective manner (7)

However, free heme can be toxic as it catalyzes the production of reactive oxygen species, oxidizes lipids and proteins, and causes DNA damage, thereby inducing a pro-inflammatory environment

Keywords: Liver disease, Hormonal imbalance, Endocrine disorders, Cirrhosis, Liver dysfunction, Liver pathology, Metabolic liver disease Core Tip: This review highlights the intricate relationship between endocrine disorders and liver dysfunction, emphasizing the role of hormonal imbalances in the development and progression of liver disease

10.1038/nature02316 62 JungY.BrackA
