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describe a mechanism in which mTORC1 activates PKC to suppress the activity of HNF4 which negatively regulates PCSK9 (11)

Preliminary evidence of a genetic association between tumour necrosis factor alpha and the severity of sleep disturbance and morning fatigue

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Notably, TMAO also amplifies ERS markers such as heat shock protein 60 and glucose regulated protein 78kD in macrophages, correlating with elevated toll-like receptor 4 expression and proinflammatory cytokine production (e.g., TNF-, IL-6) (88, 89)

[DOI] [PubMed] [Google Scholar] 47.Eguchi K., Honda M., Kataoka T., Mukouyama T., Tsuneto S., Sakamoto J., Oba K., Saji S