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Free Radical Biology & Medicine, 214 , 115128

10.1111/j.1469-8137.2008.02631.x New Phytol

The activity of AMPK rises as the energy charge falls (increasing AMP levels), therefore, it would make sense for the hepatocyte to increase energy production via glycolysis which would be enhanced by increased glucokinase activity

They may act on multiple targets simultaneously or interfere with the physiological functions of cells through a completely new mechanism of action

Zhao X, Jin L, Liu Y, Liu Z,Liu Q
