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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Lpez-Mirabal HR, Winther JR: Redox characteristics of the eukaryotic cytosol

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GSH also acts as an enzyme cofactor for GPx to degrade H 2 O 2 and hydroperoxides (ROOH), and is involved in detoxifying electrophilic xenobiotics via GSH- S -transferase (GST) [43] (Figure 2)

Most of the cellular proteins and glutathione are affected through nitration induced by RNS

de Moraes MeineBFranceschiTSBonaNPSpohrLPedraNSSpanevelloRMet alChemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver