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Patients were required to have an ECOG PS of 0 or 1

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23 Due to the superior efficacy of antioxidative enzymes in scavenging ROS compared to exogenous molecules, the antioxidative effects mediated by NRF2 are notably significant

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We found remarkably upregulated expression of the marker genes of inflammatory indicators ( TNF- , IL-6 , IL-1 , IL-23 , and Nfb1 ), chemokine CCL2 , and toll-like receptor 4 ( TLR4 , an important pathogen recognition receptor that recognizes mainly LPS of Gram-negative bacteria) in S-amlodipine-treated rats compared with control rats (Figure 2(gh))