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The findings of the aforementioned previous studies have revealed that the health implications of elevated and depleted selenium concentrations should not be assessed exclusively in the context of the serum seleniums impact on cardiovascular health

10.1126/science.279.5350.563 Science 29 ChemaitillyW.CohenL

high SAH may inhibit DNA methyltransferases (DNMTs), thus reducing methylation and causing possible uncontrolled gene expression (205)

Casadesus, J

Several types of cancer have their carcinogenesis associated with the silencing of physiologically beneficial genes, such as tumour suppressor genes, through DNA methylation, 89,90 as described earlier in the article for CDO1