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Description
This complex includes the nucleus tractus solitarius (NTS), the area postrema (AP), and the dorsal motor nucleus of the vagus nerve (DMV)
these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1
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10.1152/japplphysiol.00154.2016 104 MortonR
Author contributions XZ, YM, JM, LY and QS performed the experiments
