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2025 Sept : Substantially updated Dietary & Lifestyle Factors 2023 Nov : Updated section on green tea and epigallocatechin gallate (EGCG) in Nutrients Nov : Updated section on vitamin D in Nutrients 2022 Feb : Added section on N-acetylcysteine to Nutrients 2021 May : Updated section on green tea and epigallocatechin gallate (EGCG) in Nutrients May : Updated section on vitamin D in Nutrients 2014 Dec : Comprehensive update & review Disclaimer and Safety Information This information (and any accompanying material) is not intended to replace the attention or advice of a physician or other qualified health care professional

VEGF upregulation promotes blood vessel formation in avascular joint tissue

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We present clinical strategies for adverse event mitigation, monitoring recommendations, contraindications, and practical considerations for treatment discontinuation or switching