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HMG-CoA reductase inhibitors (statins) HMG-CoA reductase is an enzyme that catalyzes a biochemical reaction that is common to both cholesterol and coenzyme Q 10 biosynthetic pathways (see Biosynthesis)

Caffeine induces Ca 2+ release by reducing the threshold for luminal Ca 2+ activation of the ryanodine receptor

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A separate set of enzymes and transporters also plays a buffering role by eliminating acetyl-CoA from inside mitochondria created by the pyruvate dehydrogenase complex that is in excess of its utilization by the Krebs cycle

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