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The drug L-DOPA efficiently and specifically crosses the BBB via the large neutral amino acid transporter (LAT)-1 protein to enter the brain

In this context, combining MR and ICB with an additional intervention, such as a pharmacological GCN2 activator (e.g

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Disulfide bonds within these cleavable linkers remain stable in the relatively oxidizing conditions of the bloodstream but are cleaved in the reducing environment of the cytoplasm, thereby releasing the cytotoxic drug specifically within cancer cells