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As such, this new version of the manuscript tailors the original manuscript, such that the new manuscript starts with a question of the efficacy concern of CagriSema

In some embodiments, modified nucleotide is selected from the group consisting of 5-bromo-2-O-methyluridine, 5-bromo-2-deoxyuridine, 2-O-methylthymidine, 2-O-methylcytidine, 2-O-(2-methoxyethyl)thymidine and 8-oxo-7,8-dihydro-2-deoxyguanosine