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Antioxidant enzyme systems regulated by Nrf2 include MnSOD, CAT, sulfaredoxin (Srx), thioredoxin, peroxiredoxin, GPx, GR, GCL, GCS, NADPH quinone oxidoreductase 1 (NQO1), and heme oxygenase 1 (HO-1) (83)
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Chen J, Guan Z, Wang L, Song G, Ma B, Wang Y
They do not receive the same level of FDA approval as regular medications, and self-reported issues with dosing have been common
