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Impairment of fertility: In sub-chronic/chronic toxicity studies, testicular degeneration/atrophy or spermatogenesis abnormalities and a decrease in testes weight were reported in adult rats and dogs after oral administration starting at doses of 1250 mg/kg/day and 150 mg/kg/day, respectively

Covid-19 prompted the British Society of Haematology to issue pandemic B12 guidance and this outlines some of the principles for moving to oral B12 preparations
