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Spray administration: Administer a measured amount of the TB-500 nasal spray by gently pressing the applicator, releasing the spray into the subject's nostril

ICS should therefore be used with caution in patients with COPD, especially among those with a previous history of pneumonia, and if indicated, should be used in the lowest possible dose

ALT levels were determined spectrophotometrically at 450 nm and concentrations were calculated from an ALT standard curve (Tecan Reader infinite F201, Tecan)
