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Very recently, OI was reported to enhance the expression of Nrf2 and its nuclear translocation in astrocytes in an in vivo mouse hypoxic ischemic model [36]

Gradually the antioxidant scavenger system, including superoxide dismutase (SOD) with an iron core and free iron (FeIII) plays a crucial role in a further reduction to form hydrogen peroxide and/or peroxide radicals (H 2 O 2 /HO) before it is further reduced to O 2 or water (Tripathy and Oelmller, 2012

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Numerous studies have demonstrated that patients with compromised liver function due to alcohol abuse have significant reduction of Glutathione in the liver

Nitric Oxide Synthase (NOS) NOS family is formed by three isoforms: neuronal NOS (nNOS) and endothelial NOS (eNOS) are constitutively expressed and require the formation of a Ca 2+ -calmodulin complex for their activation