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The Grx(SSG) intermediate is then reduced by GSH during the reductive half-reaction, yielding the reduced enzyme and GSSG

Antioxidant systems suitable with enzymatic (e.g., SOD, catalase (CAT) and glutathione peroxidase (GPX)) and non-enzymatic (e.g., uric acid, bilirubin, vitamin E, vitamin C, glutathione (GSH), ascorbic acid, and -tocopherol) processes, both act to reduce the oxidation potential of RONS through direct and indirect mechanisms

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[DOI] [PubMed] [Google Scholar] Nguyen D, Alavi MV, Kim KY, Kang T, Scott RT, Noh YH, Lindsey JD, Wissinger B, Ellisman MH, Weinreb RN, et al