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Nature cell biology 2013;15, 978-990, doi:10.1038/ncb2784
Studies in this systematic review support B12 supplementation for the treatment or prevention of metformin-induced deficiency and neuropathy, demonstrating increased levels of B12 and decreased serum homocysteine with supplementation

You should tell your doctor if you have had, or develop, lymphoma or other cancers

Many community references include 2-4 week off-periods between cycles to allow fresh evaluation, although the rationale is community-derived rather than trial-validated
