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Using a long-term HFD-fed mouse model of NAFLD, we demonstrated in this study that NAFLD development occurs concomitantly with dysregulated hepatic glutathione homeostasis characterized by decreased GSH and increased GSSG, and increased TNF protein levels in both the circulation and the liver

AI has also shown notable advantages in diagnosing left ventricular hypertrophy (LVH)

This leads to lactate accumulation and exacerbation of the Warburg effect, further aggravating hepatocyte injury, inflammation, and fibrosis, and driving the collapse of systemic lipid, glucose, and other metabolic processes (Cheng et al., 2025)

Sirtuins and NAD(+) in the development and treatment of metabolic and cardiovascular diseases
