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Interestingly, the GSH synthesis machinery has an additional function independent of GSH synthesis under low cysteine conditions, in which -GCL ligates glutamate to other amino acids to scavenge glutamate into -glutamyl peptides and prevent glutamate toxicity [232]

doi: 10.1210/endo-92-2-423 31 ThorpePAHerbertJ

This indicates that hypoxia might contribute to the development of OA

Its also important to note that many athletes have high protein intakes in their regular diets, meaning they may be consuming large amounts of glutamine even without supplements ( Summary There is little support for the use of glutamine supplements for muscle gain or strength performance

10.1007/s11883-012-0291-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 40