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Factors such as personal pain threshold, health status, and psychological resilience significantly impact how one perceives and handles pain after surgery

There is an ongoing phase 2/3 randomised, double-blind, placebo-controlled trial (NCT06126315) of the biological and clinical effects of acetyl-l-carnitine planning to recruit ~250 patients [88]

Daniel Rader

They also mitigate Nf-B overactivated signalling, attenuating the NLRP3 inflammasome pathway and decreasing pro-inflammatory cytokines and PCR levels, thereby showcasing their immunomodulatory activities [161, 202, 217]

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