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Molecular and biochemical characterization of dehydroascorbate reductase from a stress adapted C4 plant, pearl millet [ Pennisetum glaucum (L.) R

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From the study of new phenyl dihydrouracil (PD)-based PROTACs designed by this group, PD-PROTAC 113 (SJ43489) stands out, capable of degrading the LCK protein (DC 50 = 0.8 nM) and inhibiting the cell viability of KOPT-K1 cells with nanomolar potency (IC 50 = 37 nM) 156

Selenium and ferrostatin-1 mitigate alcohol-induced oxidative damage by upregulating GPX4 and SLC7A11, with selenium exhibiting greater effectiveness [250]

Functionally, IFN-I also promoted NETs formation, ROS production, and pro-inflammatory cytokine release (Fig