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Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) (Figure 4) with three to nine carbons in length, the most reactive being ,-unsaturated aldehydes [4-hydroxy-trans-2-nonenal (HNE) and acrolein], di-aldehydes [malondialdehyde (MDA) and glyoxal], and keto-aldehydes [4-oxo-trans-2-nonenal (ONE) and isoketals] [24]

doi: 10.1016/j.jprot.2018.06.009

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TCE also disrupts cardiogenesis in human embryonic stem cells (94)

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Wu G, Fang YZ, Yang S, Lupton JR, Turner ND