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They have a dual role in biological systems, both beneficial than harmful depending on their nature and concentration as well as location and length of exposure (1)

The extensive hydrogen bonding network, highlighted by red dashed lines, induces significant steric hindrance that is critical for blocking the enzymatic access required for cell wall polymerization

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Besides, traditional chemotherapy performs a poor antitumor effect on drug-resistant glioma cells

[19] [21] Typical adult doses for the treatment of vitamin C deficiency range from 200 mg to 1 g daily, administered intravenously, with higher doses (up to 100 grams per day) reserved for specific clinical protocols under close supervision