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What Are the Mechanisms Studied for IGF-1 LR3 Signaling
(2014) identified GRL2 (Green-like 2) as a novel interacting partner of ACO1 in a yeast two-hybrid screen using GRL2 as bait and a cDNA library of petals and leaves as prey
The glutarimide moiety occupies a conserved hydrophobic pocket on the C-terminal domain of cereblon, also known as the cereblon domain, with the carbonyl groups and intervening amide interacting with His380 and Trp382 via hydrogen bonding 51
The diameter of hydrophilic or lipophilic channels can vary from 0.6 to 4.8 nm (Eichert and Goldbach 2008)
