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4.2.2 Tyrosine and phenylalanine metabolism 4.2.2.1 Production and hazards of p-cresyl sulfate (pCS) p-Cresyl sulfate (pCS) is another important protein-bound uremic toxin, formed from p-cresol produced by anaerobic bacterial degradation of tyrosine and phenylalanine through hepatic sulfation or glucuronidation (122)

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In fact, glutathione deficiency is found in almost all chronically ill patients.

While iron chelators can reduce iron load-related injury in animal models, in clinical application, attention must be paid to potential systemic side effects of long-term systemic iron chelation therapy, such as anemia, immune disorders, and metabolic abnormalities