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These monogenic syndromes, including Fragile X syndrome ( FMR1 ), Rett syndrome ( MECP2 ), PTEN hamartoma tumor syndrome ( PTEN ), tuberous sclerosis complex ( TSC1 / TSC2 ), Phelan McDermid syndrome ( SHANK3 ), and cortical dysplasia focal epilepsy syndrome ( CNTNAP2 ), play a key role in furthering our understanding of ASD

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