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The SASP can induce genomic instability in neighboring cells, creating a microenvironment conducive to tumor growth.29 Furthermore, the persistence of senescent cells in tissues can undermine the effectiveness of cancer therapies by altering immune surveillance and the tissue response to treatment.30 The Role of Senescence in Aging: A Double-Edged Sword While senescence is essential for preventing the proliferation of damaged cells and the onset of cancer, its persistent presence in tissues throughout aging disrupts homeostasis

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This includes upregulation of pro-apoptotic signaling cascades that restore controlled cellular elimination