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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Titov, D
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doi: 10.3390/nu5114521

Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

This increases the activity of sirtuins (SIRT1) and PARPs, which are essential for DNA repair and longevity