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Also, TGR5 seems to have an important role in the maintenance of intestinal barrier integrity, since murine models TGR5 deficient developed an increased intestinal permeability, made of an altered molecular architecture of epithelial thigh junctions with an increased expression and an abnormal distribution of zonulin-1 [25]

Moravek, M

The old friends hypothesis: evolution, immunoregulation and essential microbial inputs

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These combinations target complementary pathways and may provide synergistic metabolic benefits