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It can be caused by a variety of factors, including genetics, certain medical conditions, and stress
Brain Res 901:252
Tier 6 is often not subject to the coverage gap (otherwise known as the doughnut hole)
Humans obtain ERG from their diet and accumulate it in various cells and tissues (e.g., kidney, liver, central nervous system, and red blood cells) at high concentrations (100 M to 2 mM) through a highly specific ERG transporter, organic cation/carnitine transporter 1 (OCTN1) 7
