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The reality check is firm

D2KO mice exhibit an impaired thermogenesis in BAT, leading to hypothermia during cold exposure and a greater susceptibility to diet-induced obesity at thermoneutrality (104)

This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

Health benefits: Improved energy, cognitive clarity, and reduced oxidative stress

A decrease in cerebral glutathione has been observed in brain tissue undergoing oxidative stress both in aging and neurodegeneration