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In vitro , Sirt1 protein expression was significantly increased in primary hepatocytes by NNMT overexpression and was significantly decreased in primary hepatocytes by NNMT knockdown [14]

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Common Side Effects While uncommon, some people may experience mild side effects after receiving a B12 injection, including[17]: Headache Nausea and vomiting Diarrhea Fatigue or weakness Tingling or numbness in the hands and feet These effects are typically short-lived and resolve on their own