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Abstract The mechanisms of migraine pathogenesis are not completely clear, but 31 P-nuclear magnetic resonance studies revealed brain energy deficit in migraineurs

Reported clinical heterogeneity may, in part, reflect formulation-dependent variability in CoQ10 bioavailability

The mTOR protein is one of the most important regulatory elements of protein synthesis 53

The increment in intestinal permeability is another prominent mechanism in the gut-brain axis communication in patients with migraine, leading to inflammation and the release of pro-inflammatory cytokines (200, 201)

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