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Resistance of stroma-rich tumours (such as CMS4 CRC) to platinum drugs is mediated by the production of cysteine and glutathione by cancer-associated fibroblasts [28] (Fig
Memory is unreliable, especially when you are managing multiple vials or running multi-month protocols

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Some researchers report usable potency beyond 28 days, but the safety margin narrows significantly after that point

The use of deidentified human samples and data collected from the electronic health record received ethical approval from the UPenn and Roswell Park Comprehensive Cancer Center Institutional Review Boards (IRB Protocols #703185 and #BDR173423, respectively)
