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Semaglutide primarily targets GLP-1 alone, while Retatrutide extends beyond GLP-1/GIP into glucagon receptor agonism

At a cellular level, IF stimulates autophagy, promoting the clearance of damaged proteins and organelles and reducing oxidative stress within the gastrointestinal tract [73]

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In addition, a further study showed STAT3 upregulation was associated with GH hypersecretion in pituitary somatotroph adenomas (73)