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However, selling them as drugs or making therapeutic claims is illegal

In addition, berberine is believed to cause or worsen jaundice in newborns, which in a low number of cases may cause brain damage ( As such, women are advised to avoid goldenseal during pregnancy

In rare instances the injury is severe, and progresses to liver failure

doi:10.1677/joe.0.1760163 Gonzales GF, Cordova A, Vega K, et al

Mechanism of Action Ascorbic acid is necessary for collagen formation (e.g., connective tissue, cartilage, tooth dentin, skin, and bone matrix) and tissue repair