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ROS production by mitochondria can lead to oxidative damage to mitochondrial proteins, membranes and DNA, impairing the ability of mitochondria to synthesise ATP and carry out their normal metabolic functions [66]

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2.3.2 Ferroptosis and autophagy Autophagy is a cellular process characterized by the formation of autophagosomes, which are double-membrane structures that encapsulate cytoplasmic constituents and organelles for degradation

Key intervention studies have shown that GsMTx4 or siRNA-mediated silencing of Piezo1 can block mechanical stretch-induced NLRP3 inflammasome assembly, which is the mechanism underlying its ability to inhibit downstream effects (Sun et al., 2020)