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Various genetic determinants that have been identified to be related to ASD and play a role in calcium homeostasis include the NMDA receptor subunit, kainate ionotropic glutamate receptor subunit 2 (GRIK2), or metabotropic glutamate receptor genes

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The "PDA" counterion argument that arginate salt formulation constitutes a distinct compound outside the Category 2 ruling has not been validated by any FDA guidance as of this writing

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