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However, it is exciting to note that AR113 increased hepatic FXR expression accompanied by a decrease in SREBP-1C, which in turn is involved in the regulation of hepatic bile acid and lipid metabolism and maintenance of normal hepatic function

The human body naturally and continuously converts ubiquinone to ubiquinol and back again as needed within the mitochondria, making high-quality ubiquinone a highly effective, stable, and often more accessible option for long-term mitochondrial support

Furthermore, in FXN -silenced SH-SY5Y cell lines, Trolox, a lipid peroxidation scavenger and analogue of Vitamin E, improved Ca 2+ uptake and reduced lipid peroxidation (Rodrguez et al., 2020b)

These are fundamentally different approaches to studying the same overarching system