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doi: 10.1007/s10735-025-10450-2 75 ZhangY.QiaoZ.HeM.XiaJ

Among several CYBA polymorphisms, rs4673 (C242T), rs9932581 (A-930G), and rs8854 variants have been extensively studied ( CYBA promoter activity and influencing CYBA transcription ( 2 (8-isoPGF2) levels, along with reduced antioxidant CAT activity ( 2 - production have been demonstrated depending on the genotype

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Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

This process is exacerbated by smoking, pollution, exposure to UV or ionizing radiation, eating fried foods or those cooked at high temperatures, as well as engaging in high-intensity exercise (12)