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Addressing these obstacles will require the adoption of advanced computational frameworks, including bioinformatics pipelines and AI-driven integration tools, capable of harmonizing heterogeneous datasets while ensuring interpretability for clinical application (Mani et al., 2025)

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Elevated LDL-C or non-HDL-C levels in the elderly further increase the risk of heart disease in people with normal high blood pressure, according to the Cardiovascular Health Study (CHS) [125]