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Malignant neoplastic transformation takes place in several stages: in the beginning, there is intraepithelial neoplasia, from which a local prostate cancer is developed, and then, advanced prostate adenocarcinoma

[DOI] [PubMed] [Google Scholar] Meredith MJ, Reed DJ

liposomal forms absorb better, but the infusion remains the most effective route of administration

Ketteler, M., Rothe, H., Krger, T., Biggar, P

First, conjugation to sulfate or glucuronide, which generates non-toxic metabolites, and second, via the CYP450 system, which generates a toxic free-radical metabolite, N-acetyl-P-benzoquinone (NAPQI)
