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3.2.4 Pro-inflammatory factors Appropriate activation of the inflammatory response is essential for defense against injuries, but if not properly regulated, deleterious effects may occur (81)

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In addition to macrophages, neutrophils, as the earliest recruited and most abundant innate immune effector cells in periodontitis, may exhibit interactions between ferroptosis and NETosis that constitute an inflammatory amplification pathway independent of macrophages (59)

doi: 10.1016/j.ajhg.2024.09.006

[DOI] [PubMed] [Google Scholar] Grammatikopoulos G, Pignatelli M, DAmico F, Fiorillo C, Fresiello A, Sadile AG